What is SS-31 peptide and how does it work?

SS-31 (also known as Elamipretide or Bendavia) is a tetrapeptide that specifically targets the inner mitochondrial membrane. It binds to cardiolipin, a key phospholipid in mitochondria, stabilizing the electron transport chain and reducing harmful reactive oxygen species (ROS) production while improving ATP synthesis.

What makes SS-31 different from other antioxidants?

Unlike conventional antioxidants that work in the cytoplasm, SS-31 concentrates 1000-5000x inside mitochondria, targeting oxidative stress at its source. It doesn

Is SS-31 being developed as a pharmaceutical?

Yes, SS-31 (as Elamipretide) has undergone extensive clinical trials by Stealth BioTherapeutics for heart failure, Barth syndrome, and kidney injury. While some trials showed mixed results, the compound has demonstrated significant benefits in specific patient populations.

What is the typical dosage for SS-31?

Research protocols typically use 10-40mg daily via subcutaneous injection. Clinical trials have used various dosing regimens including 4mg/kg IV infusions for acute conditions. For research use, 10-20mg daily subcutaneously is common.

Can SS-31 help with aging?

Mitochondrial dysfunction is a hallmark of aging, and SS-31 directly addresses this. Studies in aged animals show reversal of age-related mitochondrial decline, improved exercise capacity, and enhanced organ function. It

Are there any side effects with SS-31?

Clinical trials have shown SS-31 is generally well-tolerated. Some patients experience mild injection site reactions. Because it enhances mitochondrial function, some users report increased energy. It

PeptideKey Research Library

SS-31 Longevity: Does It Reverse Mitochondrial Aging?

Discover SS-31 Peptide research. Learn about its mechanisms, potential benefits in studies, and essential safety considerations for experimental use.

This research guide is part of PeptideKey's evidence-based peptide research library covering 100+ compounds with lab-verified purity data.